Will a Nikon 75-300 mm Auto-Focus 1.45-5.6 AF Nokkor Lens work on a digital Nikon D80?

I have another camera/lens related question... Will the lens work on the Nikon D80?

Yes, but that is covered in the manual that came with your D80.

Take a look and you will see all the lenses that work using auto-focus, manual focus, auto-aperture, manual aperture, etc.

yes, as long as it fits. I use my old manual lenses in my nikon d1000

Yes, Nikon D80 will take all Nikkor AF lenses.